The decision was taken as part of prescribed precautions advised by the National Institute for Communicable Diseases (NICD) to limit the risk of further infection in the rugby community.
The cancellation was triggered on Saturday morning following the receipt of results from a second batch of tests on Emirates Lions senior squad playing and coaching personnel, which revealed two further positive cases.
The tests had been prompted by the recording of four other positive tests among the same group earlier in the week.
The players who tested positive and identified close contacts are isolating and quarantining according to Department of Health guidelines. The players are in good health and are being monitored by the team doctor.
If the fixture cannot be-rescheduled, both teams will take two points.
“Containing the spread of the disease is a national imperative and this first impact on the rugby schedule is a stark reminder of how vigilant our community has to be and how rigorous we must be in following the rules,” said Jurie Roux, SA Rugby CEO.
“Safety comes first, and although it is extremely disappointing for all concerned, it is a reminder to our teams and players of the role their actions will play in avoiding the risk of more cancellations.
“Despite having followed the advisory precautions and the plans that were approved by the Department of Sports, Arts and Culture (DSAC), we will take this opportunity to review them and strengthen them if required.”
The Vodacom Bulls match with the Cell C Sharks is unaffected and will continue as scheduled at 19h00 at Loftus Versfeld.