The round five encounter starts at 19h00 and is live on the SuperSport Rugby and Grandstand channels.
It will be the first time in three weeks that the team Bloemfontein will take the field following their COVID-19 interrupted third round match with the Emirates Lions and last weekend's bye.
The Emirates Lions versus Toyota Cheetahs was called off in line with COVID-19 protocols and has been declared a draw as a result of the inability to reschedule the match. Each team is therefore awarded two league points.
Amongst the Toyota Cheetahs' backs, William Small-Smith comes back into the midfield at outside centre in place of Benhard Janse van Rensburg.
In the forward pack, Aidon Davis is entrusted with the No 8 duties following the departure of Jasper Wiese to English side Leicester Tigers.
JP du Preez (lock) comes into the second row to fill the gap left by Walt Steenkamp, who has joined the Vodacom Bulls in Pretoria.
Welcome news for the Free Staters is the inclusion on the bench of Springbok loose forward Oupa Mohoje for what could be his first competitive match in more than two years on the sideline due to injury problems.
Also amongst the replacements are Phakisa Pumas recruit Jeandré Rudolph and former Cell C Sharks player Khutha Mchunu, both of whom are set to make their debuts for the Bloemfontein outfit off the bench.
Several players are still not ready for selection at the moment as a result of an assortment of injuries - they are Wilmar Arnoldi (cheek bone), Reniel Hugo (knee), Aranos Coetzee (ankle), Duncan Saal (hamstring), Ruan Pienaar (knee) and Craig Barry (knee).
Toyota Cheetahs: 15 Clayton Blommetjies, 14 Malcolm Jaer, 13 William Small-Smith, 12 Frans Steyn, 11 Rosko Specman, 10 Tian Schoeman, 9 Tian Meyer, 8 Aidon Davis, 7 Junior Pokomela (captain), 6 Andisa Ntsila, 5 JP du Preez, 4 Carl Wegner, 3 Luan de Bruin, 2 Reinach Venter, 1 Charles Marais. Replacements: 16 Jacques du Toit, 17 Boan Venter, 18 Khutha Mchunu, 19 Oupa Mohoje, 20 Jeandré Rudolph, 21 Ruben de Haas, 22 Reinhardt Fortuin, 23 Chris Smit.
Match information - Cell C Sharks v Toyota Cheetahs
Date: Friday, 6 November 2020
Venue: Jonsson Kings Park, Durban
Referee: Cwengile Jadezweni
Assistant Referees: Marius van der Westhuizen, Paul Mente
Television Match Official: Marius Jonker
TV: SuperSport Rugby and Grandstand