The match starts at 15h00 in the Diamond City and will be televised live on SuperSport channel, with Cwengile Jadezweni the man in the middle.
Both sides will be highly motivated for this match following successful outings in their previous matches.
The Northern Cape side finally got a win under their belt when they defeated Eastern Province last week in Port Elizabeth, while the Lowvelders in turn got the better of the Toyota Cheetahs.
The availability of De Beer means there are only minimal changes to the Kimberley side for their home encounter with the visitors from Mpumalanga.
De Beer starts again alongside fellow Junior Springbok Stefan Ungerer, who will again lead the side from scrumhalf.
In one of just two changes upfront, Andries Schutte is handed a debut start at tighthead prop in place of Tijde Visser, who moves to the bench, while the other change in the pack is at No 4 lock, which sees Adre Smith win promotion from the bench as he rotates places with Ewan Coetzee.
James Verity-Amm is restored to the starting team at left wing, while Enver Brandt moves down to the replacement bench.
Tafel Lager Griquas: 15 Masixole Banda, 14 Daniel Kasende, 13 Michal Haznar, 12 Andre Swarts, 11 James Verity-Amm, 10 Tinus de Beer, 9 Stefan Ungerer (captain), 8 Carl Els, 7 Stefan Willemse, 6 Gideon van der Merwe, 5 Cameron Lindsay, 4 Adre Smith, 3 Andries Schutte, 2 Alandre van Rooyen, 1 Mox Mxoli. Replacements (from): 16 HJ Luus, 17 Andrew Beerwinkel, 18 Tijde Visser, 19 Ewan Coetzee, 20 Sibabalo Qoma, 21 Ashlon Davids, 22 Johnathan Francke, 23 Enver Brandt, 24 Bandisa Ndlovu, 25 Tiaan van der Merwe, 26 Raegan Oranje.