The match at Jonsson Kings Park will be broadcast live on SuperSport at 19h00, and Marius van der Westhuizen will be carrying the whistle.
Kolisi is one of a number of players who were part of the conditioning group that will progress to match action on Friday evening.
Other returnees are Springbok props Ox Nche and Thomas du Toit, while Ruben van Heerden will partner his namesake Emile van Heerden in the second row, and Henco Venter and Sikhumbuzo Notshe complete the back row.
In the backline, former Junior Springbok scrumhalf Jaden Hendrikse will partner Boeta Chamberlain (flyhalf), with Marius Louw back at inside centre, while Sbu Nkosi is on the wing and Anthony Volmink at fullback.
Given the fact that the Cell C Sharks’ goals in this series of preparation matches were more about creating finesse around their style of play, game plan and developing depth, than the results, Yaw Penxe believes the team has really benefited.
“We did achieve what we wanted to in fine-tuning our processes, and in our losses, it was discipline here or there or just minor errors,” said the strong-running wing.
“Going into this final game, we’re looking to put everything into place and hopefully put in a really proper performance.”
Cell C Sharks: 15 Anthony Volmink, 14 Sbu Nkosi, 13 Lukhanyo Am (captain), 12 Marius Louw, 11 Yaw Penxe, 10 Boeta Chamberlain, 9 Jaden Hendrikse, 8 Sikhumbuzo Notshe, 7 Henco Venter, 6 Siya Kolisi, 5 Emile van Heerden, 4 Ruben van Heerden, 3 Thomas du Toit, 2 Fez Mbatha, 1 Ox Nche. Replacements: 16 Kerron van Vuuren, 17 Mzamo Majola, 18 John-Hubert Meyer, 19 JJ van der Mescht, 20 Phepsi Buthelezi, 21 Sanele Nohamba, 22 Rynhardt Jonker, 23 Aphelele Fassi.