Ollie Sleightholme (wing), Jack van Poortvliet (scrumhalf), Freddie Steward (fullback), and Sam Underhill (flanker) have all been included in the starting team.

Jamie George will captain England, once again supported by four vice-captains in Maro Itoje (lock), Ben Earl (No 8), Ellis Genge (prop), and George Ford (replacement flyhalf). Wing Tom Roebuck is included among the replacements for the first time this autumn.

“We're excited to challenge ourselves against the world's top-ranked team and back-to-back Rugby World Cup champions,” said Borthwick. “Test matches against South Africa are always thrilling contests, and I'm sure Saturday will be no exception.”

England team:
15 - Freddie Steward
14 - Tommy Freeman
13 - Ollie Lawrence
12 - Henry Slade
11 - Ollie Sleightholme
10 - Marcus Smith
9 - Jack van Poortvliet
8 - Ben Earl
7 - Sam Underhill
6 - Chandler Cunningham-South
5 - George Martin
4 - Maro Itoje
3 - Will Stuart
2 - Jamie George (captain)
1 - Ellis Genge
Replacements:
16 - Luke Cowan-Dickie
17 - Fin Baxter
18 - Dan Cole
19 - Nick Isiekwe
20 - Alex Dombrandt
21 - Harry Randall
22 - George Ford
23 - Tom Roebuck