Murray, the Lions' tour captain for the Castle Lager Lions Series, will lead a starting XV which has 12 changes to the team that defeated Cell C Sharks in Pretoria on Saturday evening, with Anthony Watson, Chris Harris and Dan Biggar the only players retained.
Watson shifts from right wing to fullback with Harris moving to outside centre, where he is joined in midfield by Bundee Aki. Biggar will again start at flyhalf.
“We’re pleased to have arrived in Cape Town as we near the halfway stage of the Series,” said Gatland.
“I think we’ve benefitted from playing at altitude in the first three games. While the boys have felt it in their lungs, they’ll be all the better for it now we’re at sea level.
“As we move towards the business end of the Tour, it’s pleasing to see so many players putting in some stand-out performances. As coaches we want the players to make Test selection as hard as possible and that’s we’re seeing.”
British & Irish Lions: 15 Anthony Watson, 14 Louis Rees-Zammit, 13 Chris Harris, 12 Bundee Aki, 11 Josh Adams, 10 Dan Biggar, 9 Conor Murray (captain), 8 Taulupe Faletau, 7 Tom Curry, 6 Josh Navidi, 5 Iain Henderson, 4 Maro Itoje, 3 Kyle Sinckler, 2 Ken Owens, 1 Wyn Jones. Replacements: 16 Luke Cowan-Dickie, 17 Mako Vunipola, 18 Zander Fagerson, 19 Adam Beard, 20 Tadhg Beirne, 21 Sam Simmonds, 22 Gareth Davies, 23 Elliot Daly.