Dweba’s inclusion is one of six changes to the team for the encounter with the Scottish outfit, which kicks off at 14h00 on Saturday and will be broadcast live on SuperSport.
His fellow Springboks Damian Willemse, Deon Fourie and Salmaan Moerat all come straight into the starting line-up, with Herschel Jantjies among the replacements and Marvin Orie taking the captaincy.
There are two positional switches in the backline, with Dan du Plessis at outside centre and Suleiman Hartzenberg shifting to the wing in place of the injured Seabelo Senatla, while up front Neethling Fouche comes in at tighthead prop.
DHL Stormers head coach John Dobson said that the team is looking forward to their first match at DHL Stadium since the Vodacom United Rugby Championship Grand Final last season.
“It is great to have a few of our top players back from national duty and they have all slotted in seamlessly this week," said Dobson.
“We are all looking forward to getting out there at DHL Stadium in an early game which should be a great occasion for everyone."
DHL Stormers: 15 Clayton Blommetjies, 14 Suleiman Hartzenberg, 13 Dan du Plessis, 12 Damian Willemse, 11 Angelo Davids, 10 Manie Libbok, 9 Paul de Wet, 8 Evan Roos, 7 Hacjivah Dayimani, 6 Deon Fourie, 5 Marvin Orie (captain), 4 Salmaan Moerat, 3 Neethling Fouche, 2 Joseph Dweba, 1 Ali Vermaak. Replacements: 16 Andre-Hugo Venter, 17 Brok Harris, 18 Sazi Sandi, 19 Adre Smith, 20 Ernst van Rhyn, 21 Junior Pokomela, 22 Herschel Jantjies, 23 Sacha Mngomezulu.