Lawes takes over from Owen Farrell, who is not available for this match after picking up an injury in England's victory over Australia last weekend.

Jamie Blamire will start at hooker, with props Bevan Rodd and Kyle Sinckler joining him in the front row. Locks Maro Itoje and Jonny Hill complete the tight five and Sam Underhill is at openside flanker.

Joe Marchant returns to the side on the right wing, Jonny May is on the left wing and Freddie Steward is at fullback.

As a result of Farrell's absence, Manu Tuilagi is back at inside centre, Marcus Smith is at flyhalf, and the side’s most capped-player, Ben Youngs, is at scrumhalf.

Hooker Nic Dolly could make his England debut off the bench, where he will be joined by Joe Marler, Will Stuart, Charlie Ewels, Sam Simmonds, Alex Dombrandt, Raffi Quirke and Max Malins.

England head coach Eddie Jones said: “This is our biggest game of the season and the final game of the autumn campaign and we want to finish with a bang.

“We’ve been really pleased with the preparation this week and how the team has continued to develop over the past month.

“Now we want to put on our best performance this autumn in front of a capacity 82,000 crowd at Twickenham.”

England team:
15. Freddie Steward
14. Joe Marchant
13. Henry Slade
12. Manu Tuilagi
11. Jonny May
10. Marcus Smith
9. Ben Youngs
8. Tom Curry
7. Sam Underhill
6. Courtney Lawes (captain)
5. Jonny Hill
4. Maro Itoje
3. Kyle Sinckler
2. Jamie Blamire
1. Bevan Rodd
16. Nic Dolly
17. Joe Marler
18. Will Stuart
19. Charlie Ewels
20. Sam Simmonds
21. Alex Dombrandt
22. Raffi Quirke
23. Max Malins