The decision was taken on Thursday after players and management from the Vodacom Bulls returned positive tests for COVID-19 this week.
As a result of the cancellation of the match, the encounter will be declared a draw and the teams will each receive two log points.
The other two Carling Currie Cup matches scheduled for this weekend between the Phakisa Pumas and Toyota Cheetahs in Nelspruit on Friday, and the Xerox Lions v the Cell C Sharks in Johannesburg on Saturday are unaffected.