Brace will be assisted by Jaco Peyper and AJ Jacobs from South Africa, while Marius van der Westhuizen is the TMO.
It is the second time Brace has been handed the responsibility for the league decider having held the whistle for the 2021 PRO14 Final between Leinster and Ulster in Dublin.
Brace made his league debut in September 2015 when he took charge of the match between Cardiff and Zebre, and since then has gone to referee knock-out matches in the PRO14, EPCR Challenge Cup and the Heineken Champions Cup.
In 2018, the Irish official refereed his first Tier One Test (Argentina v Wales), he was then appointed as an assistant referee for the 2019 Rugby World Cup and shortly afterwards he made his Six Nations debut in 2020 (France v Italy).
Vodacom United Rugby Championship Grand Final – DHL Stormers v Vodacom Bulls
Venue: DHL Stadium, Cape Town
SA time: 19h30
Referee: Andy Brace (Ireland, 80th league game)
Assistant referees: Jaco Peyper (SA), AJ Jacobs (SA)
TMO: Marius van der Westhuizen (SA)
TV: SuperSport, Premier Sports, RTÉ & URC TV