The match starts at 21h00 (SA and Italian time) and will be streamed via www.springboks.rugby and broadcast live on SuperSport.
Nhleko has selected a new-look front row, with Corne Lavanga, Corne Weilbach (props) and Lukhanyo Vokozela (hooker) all getting a start. They replace Lamla Nunu, Sebastian Lombard and Tiaan Lange who were the starting front trio against France.
The only other change to the pack is due to the injury to No 8 Cameron Hanekom, who has been one of the most outstanding South African forwards.
Hanekom hurt his ankle against France and is replaced by Louw Nel, with Siya Ningiza and Gcino Mdletshe providing loose forward cover on the bench. Merwe Olivier also comes onto the bench as lock alongside Corne Rahl.
Amongst the backs, scrumhalf Nico Steyn gets the starting nod in place of Neil le Roux, who is now set to join the action from the replacements’ bench.
Nhleko said the Junior Boks were mentally recharged and ready for Tuesday’s big clash.
“While we’ve managed to win three games, there is a feeling within the group that we have not played to our true potential,” said Nhleko.
“We have a sharp focus on getting our detail right, because if we do that then I believe we can increase our intensity and accuracy. Wales are a very well coached and tactically astute side and they showed their big-match temperament by beating a good Italian team in front of their home fans.”
Apart from the enforced change at No 8, the coach described the other changes as part of the overall plan.
“By the end of the tournament we would have played four very physical matches inside the space of just over three weeks and we have worked to a plan to rotate the squad so we could manage the load of the players throughout the Series, as well as give all players an opportunity to play,” he said.
“Our bench and those not in the match day squad all know they have a specific job to perform, and I must add they have done that superbly, to provide quality opposition for the starting team during our training sessions.”
Meanwhile, Nhleko cautions that Wales will be an extremely tough nut to crack in Tuesday’s late evening kick off.
“We know what they will bring - they have a formidable team, a good kicking game and serious pace out wide – so our defensive effort will have to be top-class on the day and we must take our opportunities on attack," said the coach.
“However, we have prepared well and are looking forward to the game. The boys are in a good space and they see this game as another opportunity for an improved performance.”
The Junior Springbok team to face Wales in Treviso:
15. Donovan Don (Down Touch Griffons)
14. Katlego Letebele (Vodacom Bulls)
13. Ethan James (vice-captain, DHL WP)
12. Suleiman Hartzenberg (DHL WP)
11. Imad Khan (DHL WP)
10. Sacha Mngomezulu (captain, DHL WP)
9. Nico Steyn (Lions)
8. Louw Nel (DHL WP)
7. Ruan Venter (Lions)
6. Paul de Villiers (DHL WP)
5. Reinhardt Ludwig (vice-captain, Vodacom Bulls)
4. Connor Evans (DHL WP)
3. Corne Weilbach (DHL WP)
2. Lukhanyo Vokozela (DHL WP)
1. Corné Lavagna (Vodacom Bulls)
16. Tiaan Lange (Vodacom Bulls)
17. Juann Else (Vodacom Bulls)
18. Sivu Mabece (Vodacom Bulls)
19. Merwe Olivier (Vodacom Bulls)
20. Siya Ningiza (Cell C Sharks)
21. Neil le Roux (Vodacom Bulls)
22. Duran Koevort (DHL WP)
23. Latica Nela (SA Rugby Sevens)
24. Lamla Nunu (DHL WP)
25. Corné Rahl (Cell C Sharks)
26. Gcino Mdletshe (Vodacom Bulls)