The final match of the Castle Lager Outgoing Tour kicks off at 19h30 (SA time) on Saturday.
Marcus Smith is at flyhalf and Jack van Poortvliet is at scrumhalf, while Tommy Freeman comes in at right wing, Jonny May is at left wing and Freddie Steward is full back.
Jamie George (hooker) and Mako Vunipola join fellow prop Kyle Sinckler in two changes to the starting front row. Maro Itoje and Jonny Hill stay at lock. Alex Coles comes in at flanker with Tom Curry, while Billy Vunipola is No 8.
Last weekend’s double-try scorer Will Stuart is named on the bench along with Luke Cowan-Dickie, David Ribbans, Sam Simmonds, Ben Youngs, Henry Slade and vice-captains Ellis Genge and Jack Nowell.
"This is our last game of the autumn and our chance to continue building on the improvements we have made throughout the matches," said Jones.
"We have made steady progress from game-to-game, culminating in a pulsating draw against New Zealand.
"Now we have the chance to test ourselves against the might of the world champions. We’re going out there to light the crowd up. The support at Twickenham was outstanding last week and we want to work hard on the pitch to make sure we have another atmosphere like that again on Saturday."
England team: 15 Freddie Steward, 14 Tommy Freeman, 13 Manu Tuilagi, 12 Owen Farrell (captain), 11 Jonny May, 10 Marcus Smith, 9 Jack van Poortvliet, 8 Billy Vunipola, 7 Tom Curry, 6 Alex Coles, 5 Jonny Hill, 4 Maro Itoje, 3 Kyle Sinckler, 2 Jamie George, 1 Mako Vunipola. Replacements: 16 Luke Cowan-Dickie, 17 Ellis Genge, 18 Will Stuart, 19 David Ribbans, 20 Sam Simmonds, 21 Ben Youngs, 22 Henry Slade, 23 Jack Nowell.