The encounter at Emirates Park kicks off at 14h00 and will be televised live on SuperSport.
The Highvelders were further bolstered by the return of speedy wing Edwill van Merwe, who completed his mandatory return to play concussion protocol following an incident two weeks ago against Cardiff.
Alberts returns to action from a lengthy injury layoff and combines with captain Reinhard Nothnagel in the second row.
Other changes to the starting combination from last week’s away win over Edinburgh sees Jaco Visagie and Emmanuel Tshituka getting the nod at hooker and No 6 flank respectively.
Saturday's match will also see prop Sti Sithole make his 50th appearance when he enters the action from the bench for the red and white jerseys.
Skipper Nothnagel cautioned that, although they did well to win their three tour matches in Wales and Scotland, Ulster will be a huge challenge to overcome, even though they are playing at home in front of their Lions faithful.
“Ulster is a top side and have a good track record in this competition and this certainly pose be big challenge for us,” said Nothnagel, who added that they will not be complacent despite winning all three their matches on tour.
“One of the biggest learnings for us as a team is that you must expect anything from any team in this campaign. We look forward to playing at home again in front of our home fans on what will be a great day of rugby for them.”
Emirates Lions: 15 Andries Coetzee, 14 Edwill van der Merwe, 13 Henco van Wyk, 12 Marius Louw, 11 Quan Horn, 10 Gianni Lombard, 9 Sanele Nohamba, 8 Francke Horn, 7 Ruan Venter, 6 Emmanuel Tshituka, 5 Reinhard Nothnagel (captain), 4 Willem Alberts, 3 Ruan Dreyer, 2 Jaco Visagie, 1 JP Smith. Replacements: 16 PJ Botha, 17 Sti Sithole, 18 Ruan Smith, 19 Pieter Jansen van Vuren, 20 Sibusiso Sangweni, 21 Morné van den Berg, 22 Jordan Hendrikse, 23 Zander du Plessis.